For people who are more likely to get very sick from COVID-19 infection, medications are available that can reduce your chances of severe illness and death. Other medications can help reduce symptoms and help you manage your illness.
Here’s what you need to know.
person talking on phone with healthcare provider
If you test positive and are more likely to get very sick from COVID-19, treatments are availableexternal iconexternal icon that can reduce your chances of being hospitalized or dying from the disease. Medications to treat COVID-19 must be prescribed by a healthcare provider and started as soon as possible after diagnosis to be effective. Contact a healthcare provider right away to determine if you are eligible for treatment, even if your symptoms are mild right now.
Don’t delay: Treatment must be started within days after you first develop symptoms to be effective.
People who are more likely to get very sick include older adults (ages 50 years or more, with risk increasing with older age), people who are unvaccinated, and people with certain medical conditions, such as a weakened immune system. Being vaccinated makes you much less likely to get very sick. Still, some vaccinated people, especially those ages 65 years or older or who have other risk factors for severe disease, may benefit from treatment if they get COVID-19. A healthcare provider will help decide which treatment, if any, is right for you.
Find a Test To Treat location: Use the Test To Treat (hhs.gov)external icon, or call 1-800-232-0233 (TTY 1-888-720-7489) to find a testing location that can provide treatment if you test positive.
person receiving treatment pamphlet from healthcare provider
The FDA has issued emergency use authorizations (EUA) for certain antiviral medications and monoclonal antibodies to treat mild to moderate COVID-19 in people who are more likely to get very sick.
Antiviral treatmentsexternal icon target specific parts of the virus to stop it from multiplying in the body, helping to prevent severe illness and death.
Monoclonal antibodiesexternal icon help the immune system recognize and respond more effectively to the virus. They may be more or less effective against different variants of the virus that causes COVID-19.
The National Institutes of Health (NIH) provides COVID-19 Treatment Guidelinesexternal icon for healthcare providers to help them work with their patients and determine the best treatment options for them. Several options are available for treating COVID-19 at home or in an outpatient setting. They include:
Nirmatrelvir with ritonavir (Paxlovid)external icon is an investigational antiviral treatment used in adults and children ages 12 years and older. It is taken at home by mouth (orally). It should be started as soon as possible and must begin within 5 days of when your symptoms start.
Remdesivir (Veklury)external icon is an antiviral treatment used in adults and children. Treatment requires intravenous (IV) infusions at a healthcare facility for 3 consecutive days. It should be started as soon as possible and must begin within 7 days of when your symptoms start.
Bebtelovimabexternal icon is an investigational monoclonal antibody treatment used in adults and children ages 12 years and older. A healthcare provider gives bebtelovimab as a single IV injection. It should be started as soon as possible and must begin within 7 days of when your symptoms start.
Molnupiravir (Lagevrio)external icon is an investigational antiviral treatment used in adults ages 18 years and older. It is taken at home by mouth (orally). It should be started as soon as possible and must begin within 5 days of when your symptoms start.
Some treatments might have side effects or interact with other medications you are taking. To find out if medications to treat COVID-19 are right for you, you have options:
Talk to your healthcare provider
Visit a test to treat locationexternal icon
Contact your local community health center or health department
If you are hospitalized, your healthcare provider might use other types of treatments, depending on how sick you are. These could include medications to treat the virus, reduce an overactive immune response, or treat COVID-19 complications.
Managing COVID-19 symptoms
person experiencing symptoms from COVID-19 infection
Most people with COVID-19 have mild illness and can recover at home. If you are worried about your symptoms, the Coronavirus Self-Checker can assist in the decision to seek care. You can treat symptoms with over-the-counter medicines, such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil), to help you feel better. Learn more about what to do if you are sick.
COVID-19 vaccines available in the United States effectively protect people from getting seriously ill, being hospitalized, and even dying—especially people who are boosted. As with vaccines for other diseases, you are protected best when you stay up to date. CDC recommends that everyone who is eligible stay up to date on their COVID-19 vaccines, including people with weakened immune systems.
Find a COVID-19 vaccine or booster: Search vaccines.gov, text your ZIP code to 438829, or call 1-800-232-0233 to find locations near you.
The FDA has issued an EUA for tixagevimab plus cilgavimab (Evusheld)external icon, an investigational medicine used in adults and children ages 12 years and older. Evusheld consists of 2 monoclonal antibodies provided together to help prevent infection with the virus that causes COVID-19. A healthcare provider gives Evusheld as 2 separate consecutive intramuscular (IM) injections at a doctor’s office or healthcare facility. If you are moderately or severely immunocompromised or severely allergic to COVID-19 vaccines, you may be eligible for Evusheld. Talk to a healthcare provider to determine if this option is right for you.
The right medications for COVID-19 can help. People have been seriously harmed and even died after taking products not approved for use to treat or prevent COVID-19, even products approved or prescribed for other uses. Talk to a healthcare provider about taking medications to treat COVID-19.
The use of product or manufacturer names on this page and in these resources are for informational purposes only. No endorsement, actual or implied, of those entities or products by HHS and/or CDC should be inferred. Additionally, the provision of this information should not be considered medical advice or a substitute for consulting with one’s healthcare provider.
hand holding medical light icon
For Healthcare Professionals
General Treatment Resources
COVID-19 Treatment Guidelines: What’s Newexternal icon
Coronavirus (COVID-19) Drugsexternal icon
Therapeutic Management of Nonhospitalized Adults With COVID-19external icon
COVID-19 Therapeutics Locatorexternal icon
Oral Antiviral Treatment Resources
What are Oral Antivirals?external icon
FDA Updates on Paxlovid for Health Care Providers external icon
Paxlovid Patient Eligibility Screening Checklist Tool for Prescribersexternal icon
Monoclonal Antibody Treatment Resources
Anti-SARS-CoV-2 Monoclonal Antibodiesexternal icon
What Are Monoclonal Antibodies?external icon
Coverage of Monoclonal Antibody Treatment for COVID-19pdf iconexternal icon
COVID-19 Test to Treat Locatorexternal icon
Don’t Delay: Test Soon and Treat Early pdf icon[361 KB, 1 page] | Additional Languages
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Last Updated Apr. 29, 2022
Content source: National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases